earticle

영어

Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on Alzheimer's disease (AD), type of dementia that is associated with cognitive impairment and memory loss, is poorly documented. In the present study, we investigated the drinking effects of hydrogen water on alzheimer’s patient for prevention of AD through oxidative stress and immuno redox mechanism. Alzheimer’s patients were administered with HW and purified water (PW) for 6 months. Further, we evaluated the drinking effect of hydrogen water on the cognitive impairment of AD patients by checking the serum concentration of AD biomarkers (Amyloid ; (A ) 40, 42 and tau), pro-β β inflammatory (IL-1β, IL-13), anti-inflammatory (IL-6, IL-10), macrophage activated Th1 (IL-2, IFN-γ, TNF-α, and IL-12p70), Th2 (IL-4, IL-5,) cytokines, reactive oxygen species (ROS) and nitric oxide (NO) level. We found that HW treatment significantly decrease the serum level of AD biomarker (Aβ- 40) during 6 month of treatment. In parallel, pro and anti-inflammatory cytokines were significantly inhibited in experimental group than control group. In line, macrophage activated TH1 cytokine, Th2 cytokines and ROS level were significantly decreased in HW than PW group. Likewise, HW treatment shows reduction in nitric oxide level than control group. Overall our clinical results strongly recommended that drinking hydrogen water might be a promising preventative approach for age-related neurodegenerative disease like AD and have an enormous impact on future healthcare for the elderly patients. This is the first note on the clinical application of drinking HW on the serum of AD patients.