earticle

영어

Mineral rich spring water has been used in spa and bathing purpose that often belong to traditional medicinal therapies. It also considered as a classical alternative medicine to cure the immunological disease. Recently, mineral rich containing medicine and cosmetics has been widely applied in hair loss purpose but not tried by mineral water. Therefore, the purpose of the present study is to observe the hair growth promoting effects of mineral rich spring water in SKH-1 hairless mice. We designed this study to evaluate the mineral water has hair growth promoting effect. The experimental SKH-1 hairless mice were divided into a normal control group (NC: No treatment), a positive control group (M: 3% Minoxidil), and different concentrations of mineral water group as a treatment group (MW: 2.5%, 5%, and 10%). All the test samples were topically sprayed on the three distinct parts of the leg, dorsal and a shoulder portion (about 1 cm2 areas) of the mice skin (100 L per application), twice a day, for μ 21 days. The number of hair and length was measured by taking a photograph of using the scale bar tools of the DinoCapture 2.0 digital microscope windows software. The thickness of the hair was measured by using scanning electron microscope. After 21 days of the experiment, mice treated with 2.5% mineral water showed the preferable effect on the number of hair, length, and thickness compared to the PC group and other concentration groups. However, the positive control minoxidil has no mineral containing ingredient but it has strong activity in hair growth. In our study, we found minoxidil had shown less active in hair growth effects in SKH-1 hairless mice. These results suggest that the using of optimum concentration of mineral rich spring water might have a remarked hair growth promoting effect, as observed morphologically. Collectively, according to our studies, we hypothesized that the topical application of mineral rich spring water might represent a novel strategy for the management and therapy for hair falling purpose. However, furthermore, studies could be more assured this hair growth promoting effects.