원문정보
초록
영어
Wounds are common prevalent clinical problem found in day to day life. Although numerous studies have been conducted in this field but only few studies address about the mineral effect on wound healing process. To explore the therapeutic effect of the high mineral spring water (HMW) on the wound healing process, we carried out an animal injury model for that female SKH-1 mice were divided into five groups: normal control (NC, n=10), untreated control (NT, n=10), 100 % Pure HMW (PHMW, n=10) group, 10% HMW experimental (DHMW, n=10) and two round wounds (approximately 5 mm in diameter) total of 6 round wounds were punched into each side of the superior region of the posterior extremity by biopsy puncher to each mouse. We found that HMW spraying led to an enhanced healing speed compared to untreated control group. Reactive oxygen species was suppressed in both PHMW and DHMW group compared to NT group. Collectively, our results provide the evidence that HMW might be beneficial for the treatment of skin wound injury.
목차
Introduction
Materials and Methods
1. Animals
2. Preparation of Gyeokpo natural high mineral spring water
3. Experimental Design
4. Sample Preparation
5. Determination of total Reactive Oxygen Species (ROS)
6. Determination of Nitric Oxide (NO)
7. Statistical Analysis
Results
1. Macroscopic analysis of skin wound injury treated by HMW shows injury
2. Effect of HMW on total ROS on punched wound in hairless mice
3. Effect of HMW on NO on punched wound injury in hairless mice
Discussion
Acknowledgment
Conflict of interest
References