Short tandem repeats (STRs)과 single nucleotide polymorphisms (SNPs)를 이용한 2촌 관계 분석


Using short tandem repeats (STRs) and single nucloetide polymorphisms (SNPs) for full-siblings analysis

박지혜, 문상옥, 박현철, 이동섭, 유형진, 이양한, 강필원, 김응수

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STR and SNP have been widely used genetic markers to confirm family relations. STR has been deemed very useful marker to confirm human identif ication and relations due to that everyone has different short tandem repeats (STRs) which is inhe rited indepe ndently. Des pite of weaker power of locus discrimination compared with STR, SNP features lower mutation rate (10·8) and binary polymorphism, which facilitate confirmation of family relations. In addition, applying next generation sequencing is now able to experiment larger number of SNP markers. In this study to determine relations of sibling, 17 STR and 169 SNP markers were used to see whether these markers have confidence to be used in the fi eld. 17 STR markers were detected in the full-sibling analysis and 140 SNP markers were analyzed among 169 SNP markers. When likelihood ratio value is more than 1, all true positive were detected (43 pairs), false negative were not detected and faJse positive pairs were more detected STR (47 pairs) than SNP (S pairs). Therefore FuJJ-sibJing anaJysis was efficient to use with the STR and SNP.


 I. 서론
 II. 실험 방법
  2.1 시료
  2.2 STR 분석을 위한 증폭 및 전기영동
  2.3 마커 정보 및 Multiplex PCR, DNA Chip 분석
  2.4 형제지수 분석
 III. 결과
 IV. 고찰
 V. 사사
 VI. 참고문헌



  • 박지혜 Ji-Hye Park. 국립과학수사연구원 법유전자과
  • 문상옥 Sang-Ok Moon. 광주과학수사연구소
  • 박현철 Hyun-Chul Park. 국립과학수사연구원 법유전자과
  • 이동섭 Dong-Sub Lee. 국립과학수사연구원 법유전자과
  • 유형진 Hyung-Jin Yu. DNA link Incorporated
  • 이양한 Yang-Han Leel. 국립과학수사연구원 법유전자과
  • 강필원 Pil-Won Kang. 광주과학수사연구소
  • 김응수 Eung-Soo Kim. 서울과학수사연구소 유전자분석과


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