원문정보
초록
영어
Glucagon like pepide-2, one of the GLPs, is involved in various metabolic functions in the gastrointestinal tract. It plays a major role in the regulation of mucosal epithelium and the intestinal crypt cell proliferation. Because of their therapeutic importance towards the diseases in the gastrointestinal tract, it becomes necessary to study their interaction with its receptor, GLP-2R. In this study, we have developed protein-protein docking complexes of GLP-2 – GLP-2 receptor. Homology models of GLP-2 are developed, and a reliable model out of the predicted models was selected after model validation. The model was bound with the receptor, to study the important interactions of the complex. This study could be useful in developing novel and potent drugs for the diseases related with GLP-2.
목차
1. Introduction
2. Material and Methods
2.1. Homology Modelling
2.2. Protein-protein Docking
3. Results and Discussion
3.1. Model Validation
3.2. Molecular Docking of GLP-2 Receptor – GLP-2
4. Conclusion
References