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Purpose: This study was conducted to examine the degree of suicidal ideation, social support and self-esteem on depression in middle school students. Methods: The study, based on a correlation study design, selected participants from five middle schools by convenience sampling. Data were collected from April 19 to June 13, 2015 from the 427 participants included in the study. The data were analyzed using SPSS / Win 20.0. Results: There was a significant correlation between depression, self esteem, social support, and suicidal ideation. Depression was negatively correlated with self-esteem(r=-.47, p<.001) and social support(r=-.45, p<.001), while being positively correlated with suicidal ideation(r=.64, p<.001). Conclusion: The findings indicate that depression in middle school students can increase the risk of suicide. Self-esteem and social support of middle school students are also important resources for reduce depression and suicide prevention.