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Purpose: The purpose of this study was to examine and compare the academic engagement, academic burnout, stress, and social support among undergraduate nursing students by grade. Methods: The study is a descriptive comparative survey. The participants were 247 undergraduate nursing students enrolled in 3 universities located in G city. The collected data was analyzed with descriptive statistics, x2 tests, and analysis of covariance, using SPSS/WIN 21.0 program. Results: The students showed significant differences in academic engagement, academic burnout, and stress according to their grade. The post-hoc analysis results showed that sophomores and juniors had lower academic engagement and higher academic burnout and stress than others (i.e., freshmen, or seniors). There was no significant difference in social support among nursing students. Academic engagement had a positive correlation with social support and a negative correlation with academic burnout and stress. Also, academic burnout had a positive correlation with stress and a negative correlation with academic engagement and social support. Conclusion: The findings indicate that nursing students in second and third grade were at risk of academic burnout and under severe stress. Therefore, sophomores and juniors need more attention and care to help them relieve and control stress and burnout and to improve their academic engagement. Also, the findings should be considered when developing plans and/or interventions for nursing students’ major adjustment and academic achievement.