earticle

영어

The aim of this study is to investigate whether single nucleotide poly-morphisms (SNPs) of zinc finger homeobox 3 (ZFHX3 ) gene are suscep-tibility to obesity. Recently, several study suggested that specific poly-morphisms in various genes may have effect to obesity. In present study, 54 SNPs of ZFHX3 gene were genotyped in 209 overweight and obese patients with a body mass index (BMI)≥23 kg/m2 (mean±stan-dard deviation, 44.7±6.4 kg/m2) and 159 healthy controls with a BMI of 18.5–23.0 kg/m2 (43.6±6.2 kg/m2). Genotyping of each SNP was per-formed by custom DNA chip. Logistic regression models (dominant, re-cessive, and log-additive models) were used to calculate odds ratio, 95% confidence interval, and P-values. Significant association was considered at P<0.05. Among tested SNPs in ZFHX3 genes, seven SNPs of ZFHX3 gene showed significant association with obesity (P<0.05 in each model, respectively). In conclusion, these results indi-cate that SNPs of ZFHX3 gene might be contributed to development of obesity in the Korean population.