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[PURPOSE] The study was aimed to identify the effects of Traf2 and SIRT1 on Akt aceytlation and autophagy in cardiac hypertrophy. [METHODS] We analyzed the effects of diet and exercise intervention on cardiac hypertrophy and the underlying mechanisms of TNF-α/Traf2/SIRT1 through Akt-FOXO pathway. [RESULTS] A significant up-regulation of Traf2 expression and down-regulation of SIRT1 were observed as the increase of TNF-α in cardiomyocytes. By the significant deacetylation of FOXO1 in 50 μM resveratrol treated group, we can suppose that FOXO1 is activated by SIRT1 in cardiomyocytes. Positive effects of exercise intervention remarkably inhibited the up-regulation of Traf2 expression and Akt acetylation in cardiac hypertrophy. However we could not confirm either a higher depression in Akt acetylation or the activation of FOXO1 by the SIRT1 activation. [CONCLUSION] The present study demonstrated that Traf2 served as an important mediator that enhanced cardiac hypertrophy by activating AKT pathway, and the positive effects of exercise training on the inhibition of Traf2 in cardiac hypertrophy.