원문정보
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초록
영어
Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. Hence, we have performed molecular docking of six antagonists with different inhibitory activity against UTS2R into its binding site. The binding mode of these antagonists was obtained using Surflex dock program interfaced in Sybyl-X2.0. The residues such as GLN278, THR304, TYR305, THR300, LEU299, CYS302, ASP47, TYR100 and THR304 are found in interaction between UTS2R and its antagonists. This study could be useful for identifying and analyzing the important residues involved in binding site of UTS2R receptor.
목차
Abstract
1. Introduction
2. Materials and Methods
2.1. Ligand Preparation
2.2. Protein Preparation
2.3. Molecular Docking
3. Results and Discussion
3.1. Molecular Docking
4. Conclusion
References
1. Introduction
2. Materials and Methods
2.1. Ligand Preparation
2.2. Protein Preparation
2.3. Molecular Docking
3. Results and Discussion
3.1. Molecular Docking
4. Conclusion
References
저자정보
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자료제공 : 네이버학술정보