원문정보
초록
영어
Bradykinin receptor B2 (B2R) is a GPCR protein which binds with the inflammatory mediator hormone bradkynin. Kallidin, a decapeptide, also signals through this receptor. B2R is crucial in the cross-talk between renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS) and in many processes including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Thus the structural study of the receptor becomes important. We have predicted the peptide structures of Bradykinin and Kallidin from their amino acid sequences and the structures were docked with the receptor structure. The results obtained from protein-protein docking could be helpful in studying the B2R structural features and in the pathophysiology in various diseases related to it.
목차
1. Introduction
2. Material and Methods
2.1. Peptide Structure Prediction
2.2. Protein-Protein Docking
3. Results and Discussion
3.1. Peptide Structure Prediction
3.2. Protein-Protein Docking
4. Conclusion
References