Original Article

Treadmill exercise with bone marrow stromal cells transplantation potentiates recovery of locomotor function after spinal cord injury in rats


You-Mi Kim, Tae-Beom Seo, Chang-Ju Kim, Eun-Sang Ji

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Transplantation of bone marrow stromal cells (BMSCs) is regarded as a promising candidate for the spinal cord injury (SCI). In the present study, we investigated whether treadmill exercise potentiate the effect of BM-SCs transplantation on the functional recovery in the SCI rats. The spi-nal cord contusion injury applied at the T9–T10 level using the impactor. Cultured BMSCs were transplanted into the lesion at 1 week after SCI induction. Treadmill exercise was conducted for 6 weeks. Basso-Beat-tie-Bresnahan (BBB) scale for locomotor function was determined. Sprouting axons in the lesion cavity were detected by immunofluores-cence staining for neurofilament-200. Brain-derived neurotrophic factor (BDNF) and synapsin-I expressions were analyzed using western blot-ting. BMSCs transplantation improved BBB score and increased ex-pressions of neurofilament-200, BDNF, and synapsin-I in the SCI rats. Treadmill exercise potentiated the improving effect of BMSCs trans-plantation on BBB score in the SCI rats. This potentiating effect of treadmill exercise could be ascribed to the enhancement of BDNF ex-pression in the SCI rats.


  Animals and treatments
  Spinal cord contusion injury
  BMSCs culture and transplantation
  Treadmill exercise protocol
  BBB locomotor scale
  Tissue preparation
  Western blot analysis
  Data analysis
  BBB score
  Axonal sprouting within the cavity
  BDNF expression
  Synapsin-I expression


  • You-Mi Kim Sports Science Research Institution, Korea National Sport University, Seoul, Korea
  • Tae-Beom Seo Division of Sports Science and Engineering, Korea Institute of Sports Science, Seoul, Korea
  • Chang-Ju Kim Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Eun-Sang Ji Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea


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