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Objectives: The aim of this study was to develop evaluation indicators for program implementation for drug use prevention and to provide basic data for further evaluation of drug use prevention programs. Methods: The Delphi method and in-depth interviews were used for developing evaluation indicators, including the questionnaires applied in order to develop four steps indicators of inputs, activities, outputs, and outcome. We formed a panel of 51 experts who had knowledge in the area of drug use prevention. Twenty-one experts participated in this Delphi survey. We selected the indicators according to the critical value (.42) of the content validity ratio originally proposed by Lawshe. Results: Six indicators, the ratio of related degrees or experienced instructors, a space, space for preventive education, educational equipment suitable for the program, budget for education and publicity, and preventive PR guidelines, were suggested as the input indicators. Six activity indicators were project plan report, linkage between performance indicators and program aims, network of related organizations, pre-evaluation of target subjects, the program reflecting the target population's evaluation, and feedback regarding program satisfaction With respect to output indicators, there were 8 indicators, including the number of preventive PR and education mass media PR, the number of drug use prevention programs (teacher, parent, students, etc.), the number of periodicals (periodical publications, video), the number of distribution of educational materials, the number of developing standardized drug use prevention programs, the number of implementations of the standardized program, and the final project report. Six outcome indicators, public awareness index on drug use, attitude change in the pre and post program, drug experience rate, pre-post education evaluation, program satisfaction, and institution reputation, were suggested. Conclusion: This study was the first study in Korea to develop the performance indicators for drug use prevention, promotion, and education programs. The results of this study can provide the data necessary for developing the basic framework and evaluation models for drug use prevention programs, and the development of evaluation indices in the short and long term.