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Background: The purpose of this study was to investigate the effects of kinesio taping and neuromuscular rehabilitation exercise for patients with acute whiplash-associated disorders. Methods: Twenty acute whiplash-associated disorders patients were recruited for the study. Subjects were randomly allocated into two groups. Neuromuscular rehabilitation group (NRG) received neuromuscular rehabilitation exercise, kinesio taping group (KTG) received kinesio taping. All subject was evaluated before and after intervention by their range of motion (ROM), neck disability index (NDI), numeric pain rating scale (NPRS) and fatigability. Results: First, the ROM was significantly increased in all group (p<.05). The NDI, NPRS and fatigability were significantly decreased in all group (p<.05). Secondly, NRG had significantly more increased ROM (flexion, both rotation) than KTG (p<.05). NRG had significantly more decreased NDI, NPRS and fatigability than KTG (p<.05). Conclusion: According to the results above, increased in range of motion in the neck, decreased in NDI, NPRS, fatigability were more effective in the NRG that received neuromuscular rehabilitation exercise than the KTG that received kinesio taping.