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Purpose: This cross-sectional study was carried out to identify factors influencing the health-related quality of life according to socioeconomic level during early adolescence. Methods: Participants were 617 middle school students in 1st and 2nd grade. All measures were self-administered. Data were analyzed using SPSS 21.0 program and factors affecting the health-related quality of life were analyzed by t-test, ANOVA, Duncan test, Pearson’s correlation coefficient, and multiple regression analysis. Results: According to the level of Family Affluence Scale (FAS), 19.1% of the participants were in the high class, 66.5% in the middle class, and 14.4% in the low class. We have found statistically significant differences among the high, middle, and low classes regarding the health-related quality of life, health perception, resourcefulness, family function, and social capital. The most influential factors of the health-related quality of life were found to be resourcefulness, family function, and social capital in the high and the middle class. Conclusion: The implication of this study is that it is important for the Education Ministry and middle school teachers to help adolescents develop internal coping resources as well as to develop school-curriculums considering social values and norms related to social capital in order to improving their health-related quality of life.