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Purpose: The research is a descriptive study to identify the correlations among perceived health status, self-esteem, and personality and to determine the influencing factors of perceived health status in high school students who live in Uganda. Methods: Data were collected using a questionnaire from February to May 2014. The participants were 300 students in three high schools in Uganda. The collected data were analyzed by descriptive statistics, t-test, one way ANOVA, Pearson correlation, and stepwise regression analysis using SPSS 21.0. Results: The scale mean scores (4 scale) for perceived health status, self-esteem, extraversion, neuroticism, psychoticism, and lie, the last four being the types of personality covered in the study, were 2.27±0.37, 2.27±0.31, 2.13±0.33, 2.55±0.41, 2.36±0.27, and 2.20±0.34, respectively. The variables that showed positive correlations with perceived health status were self-esteem and extraversion and the ones that showed negative correlations with perceived health status were neuroticism, psychoticism, and lie. Self-esteem, extraversion, and neuroticism were proved to be major influencing factors affecting perceived health status. Conclusion: These results may be used as supporting data when developing health education programs to improve the health of Ugandan adolescents