원문정보
초록
영어
Neuromedin, a neuropeptide, which is involved in various functions that include contractile activity on smooth muscle, controlling the blood flow and ion transport in the intestine, increased blood pressure and regulation of adrenocortical function. It is involved in the pathophysiology of various immune mediated inflammatory diseases like asthma. In this study, we have performed protein-protein docking analysis of neuromedin U – neuromedin U receptor 1 complex. We have developed homology models of neuromedin U, and selected a reliable model using model validation. The model was docked with the receptor model, to analyse the crucial interactions of the complex. This study could be helpful as a tool in developing novel and potent drugs for the diseases related with neuromedin U receptor 1.
목차
1. Introduction
2. Material and Methods
2.1. Homology Modelling
2.2. Protein-protein Docking
3. Results and Discussion
3.1. Model Validation
3.2. Molecular Docking of Neuromedin U Receptor 1- Neuromedin U
4. Conclusion
References