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Purpose: The purpose of the study is to examine the impact of job stress on the patient safety nursing activities among nurses. Methods: The subjects of the study are 258 nurses working at 15 small-medium sized hospitals in D city. Data analysis was done using frequency, percentage, average and standard deviation, t-test, one-way ANOVA, Scheffé test, Pearson's correlation coefficient, stepwise multiple regression. Results: The job stress scored average 3.67 and patient safety nursing activity scored average 4.35. Job stress was positively associated with patient safety nursing activity. It explains 9.49% of the variance. Conclusion: Universal and inevitable job stress among nurses should not exceed optimum level to assure patient safety. So, personal and organizational efforts to manage job stress are needed.