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Purpose: The aim of this study was to explore the association between psychosocial work environments and depressive symptoms among Korean registered nurses. Methods: The study population of 331 registered nurses was derived from the 2014 Korean Working Condition Survey (KWCS). Depressive symptom was assessed using the WHO-5 wellbeing index. Results: The thirty-five percentage of Korean registered nurses reported the risk for depressive symptom. Korean nurses with higher ‘work-family conflict’ were more likely at the risk of depression almost 1.83 (95% CI 1.04~3.20) times than their counterpart. Higher ‘possibilities for development’ were more likely decrease almost 60% of the risk of depressive symptom. Conclusion: Work-family conflict and possibility of development were associated with depressive symptom among Korean registered nurses. We suggest future researches identifying strategies for decreasing work-family conflict and its negative effects.