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Abstracts for poster Presentation

Synthesis of doxorubicin analogues from Streptomyces peucetius mutant

원문정보

Thuy-Van Thi Pham, Hue Thi Nguyen, Anaya Raj Pokhrel, Jae Kyung Sohng

한국당과학회 한국당과학회 학술대회 2017 한국당과학회 동계학술대회 2017.01 pp.65-65
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초록

영어

Doxorubicin (DXN) and daunorubicin (DNR) are anthracycline-type antitumor drugs. The glycosyltransferase dnrS responsible for glycosylation of DXN aglycone was disrupted from Streptomyces peucetius ATCC 27952. The mutant strain complementation with glycosyltransferases from Streptomyces galilaeus (aknS/aknT) and dimethyltransferase (desVI) from Streptomyces venezuelae caused modification in ε-rhodomycinone by transferring TDP-rhodosamine to produce an Epelmycin-D. A methyltransferase (dnrK) in S. peucetius changed that compound to 7-O-L-rhodosaminyl-4-O-methyl-e-rhodomycinone. The products were confirmed by high performance liquid chromatography-photodiode array (HPLC-PDA) and high resolution liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry (HRLC-ESI-QTOF -MS) analyses.

저자정보

  • Thuy-Van Thi Pham Department of Life Science and Biochemical Engineering
  • Hue Thi Nguyen Department of Life Science and Biochemical Engineering
  • Anaya Raj Pokhrel Department of Life Science and Biochemical Engineering
  • Jae Kyung Sohng Department of Life Science and Biochemical Engineering, Department of BT-Convergent Pharmaceutical Engineering, Sun Moon University, 70 Sunmoon- ro 221, Tangjeong-myeon, Asan-si ,Chungnam 31460, Republic of Korea

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