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Abstracts for poster Presentation

Study of C-Glycosylation of selected Flavones

초록

영어

Glycosylation reactions are widespread in nature, and involved almost all vital processes. Glycosylated compounds directly exert a wide range of functions, including energy storage, maintenance of the cellular integrity, information storage and transfer, molecular recognition, cell-cell interaction, cellular regulation, virulence and chemical defense. Glycosylated compounds are the most structurally diverse biomolecules, and their biosynthesis needs quite complex biological processes orchestrated by many enzyme systems. In Plants, various natural products are produced including diverse flavonoid derivatives. Mostly these metabolites are generally glycosides and are accumulated in the vacuole. Among C-glycosylflavones, comprising the various pharmacological activities, are biosynthesized from flavone via C-glycosylation of 2-hydroxyflavone or flavone. This is mediated by uridine diphosphate (UDP)-sugar dependent glycosyltransferase. The C-glycosyltransferase catalyzes the transfer of the glucose moiety to the aromatic carbon of the acceptor substrate. C-Glycosylflavones are involved in UV protection, defense against pathogens and inhibition of caterpillar growth. In this study, we tried to biosynthesize C-glycosylflavone in vivo and the product was confirmed by LC-MS.

저자정보

  • Anil Shrestha Department of Life Science and Biochemical Engineering
  • Vijay Rayamaihi Department of Life Science and Biochemical Engineering
  • Dipesh Dhakal Department of Life Science and Biochemical Engineering
  • Jae Kyung Sohng Department of Life Science and Biochemical Engineering, Department of BT-Convergent Pharmaceutical Engineering, Sun Moon University, 70 Sunmoon- ro 221, Tangjeong-myeon, Asan-si ,Chungnam 31460, Republic of Korea

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