earticle

논문검색

Abstracts for poster Presentation

Application of Modified Target Moiety Low Molecular Water Soluble Chitosan-graft-Branched Poly(Ethylene imine) Copolymer for Gene Carrier

초록

영어

Gene therapy is the introduction of genes into cells or tissues to up- or down-regulate genes that can remove the pathological symptoms or activate the immune response via the delivery of DNA or RNA. This treatment has great promise for preventing or curing a wide range of diseases. In the present study, a RGD peptide and PEI grafted water soluble chitosan (RPgWSC) copolymer was synthesized and its efficiency as gene carrier investigated. The physiological characters, in vitro targeted gene transfection, cytotoxicity, blood-compatibility, and cellular distributions were investigated. In particular, a study of the endocytic mechanism resulted in the microtubule-dependent macropinocytosis and clathrin-mediated endocytosis.

저자정보

  • Young-min Kim Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea
  • Nam-Hong Kim Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea
  • Eun-ji Kim Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea
  • Huk-Jin Seo Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea
  • Seong-Cheol Park Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea
  • Mi-Kyeong Jang Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea

참고문헌

자료제공 : 네이버학술정보

    ※ 원문제공기관과의 협약에 따라 개인회원에게 무료로 제공됩니다.

    0개의 논문이 장바구니에 담겼습니다.