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Abstracts for Colloquium

Sugary interfaces mitigate contact damage where stiff meets soft

초록

영어

The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose binding domains has been characterized from Atrina’s foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3+–DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA- and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices.

저자정보

  • Hee Young Yoo 유희영. Division of Integrative Biosciences and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea
  • Mihaela Iordachescu Division of Integrative Biosciences and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea
  • Jun Huang Department of Chemical and Materials Engineering, University of Alberta, Edmonton, T6G 2V4, Canada.
  • EliseHennebert Laboratory of Biology of Marine Organisms and Biomimetics, Research Institute for Biosciences, University of Mons, Mons, Laboratory of Cell Biology, Research Institute for Biosciences, University of Mons, Mons, 7000, Belgium.
  • Sang sik Kim School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
  • Sangchul Rho Center for Plant Aging Research, Institute of Basic Science, Daegu, 42988, Republic of Korea.
  • MathiasFoo School of Engineering, University of Warwick, Coventry CV4 7AL, UK.
  • PatrickFlammang Laboratory of Biology of Marine Organisms and Biomimetics, Research Institute for Biosciences, University of Mons, Mons, 7000, Belgium
  • HongboZeng Department of Chemical and Materials Engineering, University of Alberta, Edmonton, T6G 2V4, Canada.
  • DaeheeHwang Center for Plant Aging Research, Institute of Basic Science, Daegu, 42988, Republic of Korea, Department of New Biology, DGIST, Daegu 42988, Republic of Korea.
  • J. Herbert Waite Deparment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California, 93106 USA.
  • Dong Soo Hwang Division of Integrative Biosciences and Bioengineering, Pohang University of Science and Technology, Pohang, School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.

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