Abstracts for Colloquium

The Road to Glycan and Glycopeptides Analysis without Compromise



Characterizing and monitoring the glycan population of a biotherapeutic protein has continued to present technical and logistical challenges to the biopharmaceutical industry. Improvements to analytical technologies and informatics have made the process quicker and more automated, but overall laboratory workflows for released glycan analysis have continued to be laborious and require high skill to generate accurate and reproducible profiles. Electron transfer dissociation(ETD) is a powerful fragmentation technique known to be particularly useful for determining sites of labile post-translational modifications(PTMs), which are often more difficult to characterize using collision induced dissociation (CID). This seminar offers details of glycopeptide characterization using ETD fragmentation.


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