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학생구두발표

Anti-osteoporotic and immunostimulating activity of Camellia oleifera polysaccharides in RAW 264.7 macrophage cells

초록

영어

Recently, researches on plant polysaccharides have been increasingly important topics for the development of therapeutics for various diseases due to their multiple biological properties including anti-inflammation, wound healing, anti-hepatitis, anti-ulcer, and anti-neoplastic effects. The Camellia oleifera has been used extensively as cooking oil and traditionally applied as a medicine for stomachache and burning injury in China. The objectives of this study was to investigate the anti-osteoporotic effect and immunostimulating activity of Camellia oleifera polysaccharides (COP). Polysaccharides were isolated from the defatted C. oleifera seeds mainly by water extraction and 75% ethanol precipitation. Monosaccharide composition analysis by HPEAC-PAD showed that these polysaccharides consist of rhamnose, arabinose, galactose, glucose, and xylose as the major neutral sugars. COP was not toxic at up to 500 μg/ml in RAW 264.7 cells, and increased immunostimulating cytokines (TNF-α and IL-6) secretion in a dose-dependent manner. In addition, COP inhibited the receptor activator of NF-кB ligand (RANKL)-induced tartrate-resistance acid phosphatase (TRAP) activity and the formation of multinucleated osteoclasts. These results suggest that the COP may have potential anti-osteoporotic activity.

저자정보

  • Chang Won Lee Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea
  • Jeong Yeon Seo Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea
  • Sarang Cho Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea
  • Seong Cheol Kim Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea
  • Yong Il Park Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea

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