원문정보
초록
영어
In spite of beneficial roles of many flavonoids against various diseases including diabetes, cardiovascular diseases, autoimmune diseases, ulcer and inflammation, their physiochemical natures such as stability and solubility limit clinical and industrial applications. Glycosylation of natural flavonoids has been reported to influence their adsorption, distribution, metabolism, and excretion properties. The present study aimed to investigate and compare biological activities of various natural flavonoids (NF) and their glycosylated derivatives (GF) in several disease models in vitro. The results showed that anti-cancer activities of several NF in various cancer cell lines were significantly reduced or even completely abolished by glycosylation of NF. In contrast, quercetin 3-O-xyloside greatly increased cytokine (TNF- α) secretion in RAW264.7 cells whereas quercetin aglycon and it's glycosylation with rhamnose and glucose reduced TNF-α secretion. Comparing to quercetin aglycon, quercetin 3-O-glucoside significantly reduced lipid accumulation in adipocytes whereas glycosylated quercetin having xylose or rhamnose stimulated the lipid accumulation. These results showed that glycosylation to the specific position of certain flavonoid with specific sugar residue could enhance immune modulation and anti-obestiy activities.