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Abstracts for poster Presentation

Ganglioside is Important Marker in Osteoblast Differentiation of Adipose-Derived Mesenchymal Stem Cells from Mini-Pig

원문정보

Sung Youn Heo, Dong Hoon Kwak, Yu Na Seo, Won Seok Ju, Hyun Gyu Lim, Seo Yi Lee, Ji-Su Kim, Kyu-Tae Chang, Young-Kug Choo

한국당과학회 한국당과학회 학술대회 2016 한국당과학회 하계학술대회 2016.07 pp.29-29
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초록

영어

Mesenchymal stem cells can differentiate into multiple lineages depending on their exposure to differing biochemical and biomechanical inductive factors. The Ganglioside is included in biomarker, that are the major component of cytoplasmic cell membranes complex glycosphingolipids, and play a role in the control of biological processes. However, role of ganglioside in osteogenesis of mini-pig adipose derived mesenchymal stem cells (AD-MSCs) unclear . We have knocked down was ganglioside synthase UDP-glucose ceramide glucosyltransferase (UGCG)using a siRNA differentiation into osteoblast was markedly decreased in UGCG-knocked down AD-MSCs. The results showed significant inhibits alkaline phosphatase, osteocalcin, osteopontin, and Runt-related transcription factor 2 in UGCG knock down AD-MSCs compared to with the control AD-MSCs. Thus we guess, maybe ganglioside is essential factor to stimulate osteogenesis in AD-MSCs.

저자정보

  • Sung Youn Heo Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea
  • Dong Hoon Kwak Institute for Glycoscience, Wonkwang University, Iksan 570-749, Jeonbuk, Korea
  • Yu Na Seo Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea
  • Won Seok Ju Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea
  • Hyun Gyu Lim Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea
  • Seo Yi Lee Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea
  • Ji-Su Kim National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, chungbuk 363-883, Korea
  • Kyu-Tae Chang National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, chungbuk 363-883, Korea
  • Young-Kug Choo Department of Biological science, College of Natural Sciences, Wonkwang University, Institute for Glycoscience, Wonkwang University, Iksan 570-749, Jeonbuk, Korea

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