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Abstracts for poster Presentation

The Regulatory Role of Ganglioside GM2 and GD3 in Differentiation of Mini-Pig Adipose-Derived Mesenchymal Stem Cells into Neuronal Cells

초록

영어

Gangliosides are glycolipid having sialic acid. It is present in the central nervous system and involved in multiple functions of cell membranes and nerve function. However, roles of gangliosides in the differentiation of mesenchymal stem cells (MSCs) is unclear. Therefore, we investigated the effects of ganglioside in neuronal differentiation of adipose-derived MSCs (AD-MSCs). In the differentiated neuronal cells from AD-MSCs. we observed the expression of neuronal markers (MAP-2 and GFAP) and the high levels of mRNA expression of neuron-specific genes. Also, The expression of ganglioside GM2 and GD3 were significant increased in neuronal differentiation of AD-MSCs. In addition, this study showed that differentiation of AD-MSCs into neuronal cells significant decrease in the knockdown of UDP-glucose ceramide glucosyltransferase (UGCG) which well known as first step of ganglioside synthase and beta-1,4-N-acetyl-galactosaminyl transferase 1(B4GALNT1) gangllioside GM2 synthase. The results indicate that ganglioside GM2 and GD3 might be important roles in the neural differentiation of mini-pig AD-MSCs.

저자정보

  • You Na Seo Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea
  • Dong Hoon Kwak Institute for glycoscience, Wonkwang University, Iksan, Jeonbuk 570-749, Korea
  • Soung-Yun Heo Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea
  • Won Seok Ju Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea
  • Hyun Gyu Lim Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea
  • Seo Yi Lee Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea
  • Sun-Uk Kim National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, Chungbuk 363-883, Korea
  • Ji-Su Kim National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, Chungbuk 363-883, Korea
  • Kyu-Tae Chang National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, Chungbuk 363-883, Korea
  • Young-Kug Choo Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea, Institute for glycoscience, Wonkwang University, Iksan, Jeonbuk 570-749, Korea

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