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Abstracts for Poster Presentation

Preparation and Characterization of Active Molecular Chitosan (AMC-S1)

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The aim of the present study is to prepare the chitosan hydrolysates and characterize their potential antibacterial activity. High molecular weight chitosan (CTSN-H) and medium molecular weight chitosan (MMWC, 2~10-kDa) were further degraded efficiently by using chitosanase from Bacillus subtilis JH-1122. Molecular weight (MW) of the final product was determined by MALDI-TOF MS, showed several peaks ranging from 0.8 to 2.5-kDa. Based on antibacterial activity of the hydrolysates, final products were named as active molecular chitosan (AMC-S1). AMC-S1 was evaluated as IC50 to 12.5 mg/mL of the concentration toward Candida albicans. Our present study demonstrates that AMC-S1 derived from the digestion of CTSN-H and MMWC can be selected as a potent factor affecting on antimicrobial activity against C. albicans for the industry and pharmaceutical applications.

저자정보

  • Joo Won Kim Department of Life Science, College of Bionano, Gachon University
  • Eui Jae Jung Department of Life Science, College of Bionano, Gachon University
  • You Jin Hwang Dept. Biomedical Engineering, College of Health Science
  • Jae Kweon Park Department of Life Science, College of Bionano, Gachon University

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