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Abstracts for Poster Presentation

Redox-responsive nanophotosensitizer composed of chlorin e6-conjugated dextran for photodynamic treatment of colon cancer cells

원문정보

Young-IL Jeong, Hye Lim Lee, Tae-Won Kwak, Dae Hwan Kang

한국당과학회 한국당과학회 학술대회 2016 한국당과학회 동계학술대회 2016.01 pp.68-68
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초록

영어

We synthesized dextran-chlorin e6 conjugates having disulfide linkage for photodynamic treatment (PDT) of colon cancer cells. Cystamine was conjugated to reductive end group of dextran and then amine end group of dextran-cystamine conjugates were conjugated with chlorin e6 (Ce6). Dextran-Ce6 conjugates having disulfide linkage (DEX6ss) has small particle sizes less than 100nm and spherical shapes. Ce6 was released from nanoparticles by responsive manner with glutathione concentration and dextrase. DEX6ss nanoparticles were efficiently delivered to HCT116 colon carcinoma cells compared to Ce6 itself. ROS production and phototoxicity of DEX6ss nanoparticles were significantly higher than Ce6 itself. In animal tumor xenograft model, tumor targetability of DEX6ss nanoparticles was significantly higher than Ce6 itself. These results indicating that DEX6ss nanoparticles have redox and colonic enzyme-responsiveness as a tumor targetable photosensitizer.

저자정보

  • Young-IL Jeong Biomedical Research Institute, Pusan National University Hospital, Pusan 602-739, Republic of Korea
  • Hye Lim Lee Biomedical Research Institute, Pusan National University Hospital, Pusan 602-739, Republic of Korea
  • Tae-Won Kwak Biomedical Research Institute, Pusan National University Hospital, Pusan 602-739, Republic of Korea
  • Dae Hwan Kang Biomedical Research Institute, Pusan National University Hospital, Pusan 602-739, Republic of Korea

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