원문정보
초록
영어
Galectin-3, a member of carbohydrate recognition protein, is often over-expressed in cancerous regions, compared to normal counterparts. Moreover, this altered galectin-3 expression correlates with the aggressiveness of the tumor and the acquisition of the metastatic phenotype, indicating that galectin-3 might modulate tumor progression and influence disease outcome. It is important to note that a change in the subcellular localization of galectin-3 occurs during the transition from normal cells to cancer cells. In this study, it deals with the underlying mechanism that galectin-3 enhances gastric cancer cell survival and motility. Therefore, we suggest that galectin-3 can serve as potential target molecule in the prevention and/or therapy of gastric cancer.