earticle

영어

Polymeric nanoparticles based on natural polymer have been investigated due to low cytotoxicity, biocompatibility, and non-immunogenicity. In particular, chitosan has many advantages in this regard, but has to overcome the obstacles such as low bioavailability and gene expression level. For this object, ligand molecules binding with targeting receptors which are overexpressed in pathogen or tumor cells provides immense opportunities for the concentrative delivery of bioactive cargos into targeting cells and the minimum toxicity in normal cells. Therefore the conjugation of a pathogenic cell-specific ligand molecules to polymeric nanoparticles is an important strategy in the design of drug delivery carrier. The present studies describe a notable use of antifungal peptide as targeting ligand toward fungal pathogen and the applications of new ligands in tumor gene therapy.