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Objectives : The purpose of this study was to identify mediating effects of nursing professionalism on the relationship between image of nurses and satisfaction with nursing as a major among nursing students. Methods : A self report questionnaire survey was completed by 429 nursing students in 1 university in K city. Data were collected between April 25 and May 06, 2016 and analyzed using the SPSS 21.0 program. Results : The nursing students recognized that image of nurses had a positive (+) effect on nursing professionalism and satisfaction with nursing as a major, and nursing professionalism had a positive (+) effect on satisfaction with nursing as a major. Further, nursing professionalism had significant partial mediating effect on the relationship between image of nurses and satisfaction with nursing as a major. Conclusions : These results indicate that nursing professionalism has a positive mediating role on the relationship between image of nurses and satisfaction with nursing as a major among nursing students. Therefore, in order to promote satisfaction with nursing as a major in nursing students, it is necessary to develop and implement educational programs that can form a desirable image of nurses and nursing professionalism.