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Purpose: The purpose of this study was to identify ego-resilience, self- leadership, stress coping which might influence job satisfaction in ED nurses. Methods: Data were collected by self-reporting questionnaires from 123 nurses in 10 EDs. Data analysis was done with SPSS/WIN 18.0 program. Results: Job satisfaction showed statistically significant differences depending on age, academic background, religion, clinical career, clinical career in emergency department, position, sleeping hour and reason for working. Job satisfaction showed significantly positive correlations with ego-resilience (r=.70, p<.001), self-leadership (r=.46, p<.001) and stress coping (r=.57, p<.001). Ego-resilience (β=.54), sleeping hours over 8 hours (β=.17) and reason for working (β=.17) were significant predictors and accounted for 56.6%. Conclusion: Based on these results, it is needed to develop a program in order to improve ego-resilience of ED nurses.