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Objectives: The objective of this study is to evaluate the correlates of depression and perception gap of adolescents’ Health-Related Quality of Life (HRQOL) between Parents and Children. Methods: Research targets are all students and their parents who are enrolled in from 1st~3rd grade of middle school to 1st grade of high school which was selected intentionally. The survey was conducted from May 16th to June 9th in 2014 by research staffs equipped with structured questionnaire. PedsQLTM4.0 Generic Core Scales and Korean form of the Kovacs’ Children’s Depression Inventory were the main tool for measuring the HRQOL and depression. Data of 985 respondents, both of parents and children, was used for analysis of this study. Results: In terms of gender difference of depression, 5.8% of adolescents, 3.2% of male and 8.5% of female (p<0.001), are shown depression symptom. Depression rate of the low level students of academic achievement was 11.0% which is the lowest rate to compare to 4.3% of middle level and 2.6% of high level students (p<0.001). The case that parents overestimated their children’s overall HRQOL is 3.699 times more likely to have depression symptom than the case which is in concurrence between parents and children. Especially the overestimation in social, emotional, and academic area of HRQOL promote depression 3.918 times, 3.371 times, and 2.258 times more than the agreement occurred of each areas. In contrast underestimation in physical area of HRQOL reduce depression 0.266 times less than the agreement occurred of the area. Conclusion: The perception gap of adolescents’ HRQOL between parents and children is the most influential factor to adolescents’ depression among all variables which was evaluated in this study.