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Objectives: The working environment affects employees’ physical and mental aspects, and has a deep associations with depression. The purposes of this study are to investigate how hazardous environment working experience impacts on depression, to provide rationale and practical implications for reducing depression and drinking. Methods: This study targeted 215 dental hygiene students from 3 universities located in Gyeonggi-do from November 30 to December 4, 2015. We analyzed the data with frequency analysis, descriptive statistics, t-test. One-way ANOVA, Pearson correlation coefficient, Regression analysis by using SPSS. Results: This study showed that experience working in hazardous environments increased depression and alcohol drinking, on the other hand alcohol drinking reduced depression. In addition, experience working in hazardous environments effected on depression indirectly through mediating of drinking, subjective health had not role of Moderating Effects between experience working in hazardous environments and depression. Conclusions: In order to reduce workers’ depression and alcohol, the improvements of harmful environment are needed. For this governments and local governments should efforts to support enhancing workplace environment, to develop model of standard work environment, and to change employers’ awareness on the harmful environment.