원문정보
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초록
영어
Urotensin-2 receptor (UTS2R) is the most potent vasoconstrictor and plays a major role in the pathophysiology of various cardiovascular diseases and becomes a potential target for human pharmacotherapy. The crystal structure of Urotension-2 receptor has not yet been resolved. Hence, in the current study homology modelling of UTS2R was done utilizing the crystal structure of human delta opioid receptor as the template. Since the template has low sequence identity, we have incorporated both comparative modelling and threading approach to generate the three dimensional structure. 10 models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of UTS2R.
목차
Abstract
1. Introduction
2. Materials and Methods
2.1. Template Selection
2.2. Model Generation
2.3. Model Validation
3. Results and Discussion
3.1. Template Selection
3.2. Model Generation and Validation
4. Conclusion
References
1. Introduction
2. Materials and Methods
2.1. Template Selection
2.2. Model Generation
2.3. Model Validation
3. Results and Discussion
3.1. Template Selection
3.2. Model Generation and Validation
4. Conclusion
References
저자정보
참고문헌
자료제공 : 네이버학술정보