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Review Article

Matrix metalloproteinase and tissue inhibitor of metalloproteinase responses to muscle damage after eccentric exercise

원문정보

Jooyoung Kim, Joohyung Lee

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초록

영어

High-intensity eccentric exercise is known to induce muscle damage leading to inflammatory responses and extracellular matrix (ECM) deg-radation. These degradation processes involve enzymes such as matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). MMPs are calcium and zinc-dependent proteolytic enzymes that play a role in ECM degradation and recruitment of inflammatory and myogenic cells into the damaged site. In contrast, TIMPs inhibit MMP-induced ECM degradation to maintain normal homeostasis in ECM. Recently, several studies have examined the process of muscle remodeling and the roles of ECM, MMPs, and TIMPs in exercise-in-duced muscle damage. However, the results of these studies are not in-consistent. In the present mini-review, we will discuss the responses of MMP and TIMP to eccentric exercise based on the literature review.

목차

Abstract
 INTRODUCTION
 MATRIX METALLOPROTEINASE IN SKELETAL MUSCLE
 TISSUE INHIBITOR OF METALLOPROTEINASE IN SKELETAL MUSCLE
 MATRIX METALLOPROTEINASE AND TISSUE INHIBITOR OF METALLOPROTEINASE RESPONSES TO ECCENTRIC EXERCISE
 CONCLUSIONS
 CONFLICT OF INTEREST
 REFERENCES

저자정보

  • Jooyoung Kim Sport, Health, and Rehabilitation Major, Kookmin University, Seoul, Korea
  • Joohyung Lee Sport, Health, and Rehabilitation Major, Kookmin University, Seoul, Korea

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자료제공 : 네이버학술정보

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