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Studies on the Effect of Molecular Weight on Biodegradable Polymer Membrane

초록

영어

PLA and PLGA have been extensively used for controlled drug delivery and used to fabricate device for tissue engineering. The objective of the present study was to know the effect of different molecular weight of PLLA and PLLGA. PLLA and PLLGA membrane was prepared using a solvent-casting method. In vitro degradation of the blank membrane was characterized by techniques including NMR, SEM, BET. And examined the degradation of PLA-PGA copolymer at different temperature range. The lower molecular weight, the more porosity and the smaller pore size. The degradation ratio of membrane increased with increasing test temperature.

목차

Abstract
 1. Introduction
 2. Materials and Methods
  2.1. Materials
  2.2 Preparation of Membranes
  2.3. In vitro Degradation of Membranes
  2.4. Differential Scanning Calorimeter (DSC)
  2.5. Scanning Electron Microscopy (SEM)
  2.6. Brunauer Emmett Teller (BET)
 3. Results
  3.1 The Glass Transition Temperature of Membranes
  3.2 Morphological of Blank Membranes
  3.3 Pore Size and Porosity of PLLA and PLLGA Membranes
  3.4 Weight loss of PLLGA membranes
  3.5 Media pH Measurements
 4. Conclusions
 References

저자정보

  • Yuying Xie Dept. Of Environment Eng., Sunmoon University,Korea
  • Jong-soon Park GLO-ONE Co Ltd. Korea
  • Soon-kook Kang Dept. Of Environment Eng., Sunmoon University,Korea

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