earticle

영어

The research of the chromosomal positions enrichment of genes is a method widely used to characterize a set of genes. Several software tools are now available for this analysis, such as GSEA, CROC, ChromoScan. So far, however, there is still no suitable tool for detecting enriched microRNA-regulated target genes sets on chromosomes. Here, for the first time, we have developed MTGCFinder, an online tool for mining microRNA-regulated target genes clusters on chromosome. The sliding window algorithm is provided to mine the target genes clusters on chromosome segments, and according to the needs of the specific issues, users can set the window size themselves. At the same time, it also provides a search for the enrichment of all microRNA-regulated target genes on chromosomes/regions in number of species. In order to further study the relationship between microRNA and human cancer, MTGCFinder also provides the function for mining cancer-related microRNA target genes clusters on chromosome regions, which is helpful for the study of human cancer.