earticle

영어

The growth factor(GF) of cell is combined with accepter in the surface of epithelium system cell membrane and then serves as a sort of intermediary to convey that information to the inside of cell. These intermediaries that include IFG-I, KFG, FGF 1, FGF 2, FGF 5, VEGF and TGF-αβ control growth factor. Among hair growth factors, epidermal growth factor(EGF) and transforming growth factor(TGF-β) have an effect on curbing hair growth, whereas insulin-like growth factor(IGF-I) and hepatocyte growth factor(HGF) function as a stimulator to give stimuli to functional activities. Insulin-like growth factor regulates not only sugar blood concentration but the generation of arachidonic acid, which is essential fatty acid, one of fundamental hormone components. Eicosanoid hormone that is one of male hormone components controls keratinocyte and that is created in proportion to the generation of arachidonic acid That has a firsthand impact on the generation of TGF-I in dermal papilla cells that contain an accepter of male hormones. Accordingly, IGF-I is created by dermal papilla cells, and that stimulates the functionally activated growth of cultivated outer root sheath of hair cell. But dermal papilla cells had an effect on suppressing the growth of keratinocyte. What produces such an inhibition effect isn't evident. One possibility is that an inhibitor might be generated, and another possible cause might be a decrease in the number of cells that stimulate it through dermal papilla cells.