원문정보
초록
영어
For treating the chronic illnesses, the best choice of drug delivery might be the controlled drug delivery systems. Nanoscaled drug delivery systems like nanofibres, nanoparticles are in the advancement of the controlled drug delivery system. Nanofibres are being a good choice due to its advantages like high drug loading and encapsulation efficiency. The present study is concerned with the synthesis of simple electrospunned nanofibres of Chitosan (CHI)/Polyvinyl alcohol (PVA) blended with Hydroxy ethyl cellulose (HEC) which will be preloaded with a model chemotherapeutic agent 5-Fluorouracil (5-FU) before electrospinning. HEC is chosen for its capability of enhancing the nanofiber formation since it is used as the thickening agents in several fields. The various mixture proportions of HEC and PVA blends were tried to form electrospunned fibers and characterized usingFT-IT, SEM, TGA and UV-VIS (for drug release study). The data output strengthening that HEC might be used to get the optimum nanofibre in the CHI/PVA nanofibre preparation which may be useful for controlled releasing of the drugs like 5-FU for treating colo-rectal cancer like chronic illnesses.
목차
1. Introduction
2. Experimental
2.1. Materials
2.2. Preparation of Composite Polymers/HEC Solution Containing 5-FU
2.3. Electrospinning
2.4. Characterization of 5-FU Containing CHI-PVA-HEC Nanofibrous Blend
2.5. Drug Entrapment Efficiency
2.6. Degree of Swelling
2.7. In Vitro Drug Release Studies
3. Results and discussion
3.1. Scanning Electron Microscopy (SEM)
3.2. FT-IR Spectroscopy
3.3. Thermo Gravimetry Analysis
3.4. Drug Entrapment Efficiency
3.5. Degree of Swelling of the Drug Loaded Composite Nanofibres
3.6. In Vitro Release of Drug
4. Conclusion
Acknowledgements
References