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This study was conducted with the aim of providing baseline data for the establishment of policies for system enhancement, by identifying the influences of work satisfaction and job stress on turnover intention within the nursing force in the Comprehensive Nursing Service ward, a newly adopted service, and the General ward. The study subjects were nurses in the General and Comprehensive Nursing Service wards at two hospitals in Seoul, and one in Gyeonggi region. The survey was conducted in the form of a self-administered questionnaire. The study discovered no significant disparities between the two groups, with regard to the salience of the variables, namely, turnover intention and work satisfaction and job stress levels. In both groups, there was a significant negative correlation between work satisfaction level and turnover intention, and between turnover intention and job stress level. Moreover, in both groups, work satisfaction and job stress levels had significant influences on turnover intention. In conclusion, to enable the establishment of the Comprehensive Nursing Service ward system as an effective healthcare management system, nurses’ work satisfaction and job stress levels must become critical factors of consideration. It is necessary for the system to evolve into a form that is satisfactory to patients, families, and nurses.