earticle

영어

Epigallocatechin Gallte (EGCG) is studied as a functional material for cosmetics, foods and medications due to the various bioactive feature as a major constituent of catechins containing lots of green tea polyphenols. EGCG has a unique phenolic structure, and its structure is largely involved by the number of hydroxyl. Especially the antioxidant activity is shown since the OH radical and gallate are engaged. Also, it reduces manifestation of matrix metallo proteinases, and restrains mitogen activated protein kinase’s extracellular signal-regulated kinase-1/2, c-Jun N-terminal hinase and p38, which are activated by ultraviolet (UV)B on mouse skin. It restrains activation of tyrosinase by UV rays, and growth of cancer cells by affection of G1 regulatory enzyme of cell cycle such as cyclin-dependent kinases. It is only restrains proliferation of P. acnes while treating EGCG, but also shows the effectiveness of reduction on manifestation and production of interleukin (IL)-6, IL-8 and tumour necrosis factor-a, which are cytokines related to inflammation. In addition, it helps breaking down of body fat, detoxification function on heavy metals, antidiabetic effect, stimulating hair growth and preventing periodontitis. Now, we are going to study on the major physiological function of this EGCG.