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Thiourea is used in photography, pharmaceutical and pesticide manufacture and in textile chemicals. It is recorded on High Product Volume list of Organization for Economic Cooperation and Development presently. But thiourea is a carcinogen and mutagen and this chemical is on the Special Health Hazard Substance List(U. S. Environmental Protection Agency). It has been shown to cause thyroid, liver and other cancers in animals. Exposure can damage the bone marrow causing reduced red blood cell, white cells and reduced platelets. Repeated exposure can cause goiter and causes reduced thyroid hormone. High Performance Liquid Chromatography/Ultra Violet Detector method of thiourea on Occupational Safety and Health Administration has a complex process and bad repetition. so superior method is needed. The aim of this study is making the method. thiourea and 1 ,1,3,3-tetraethoxypropane make 2-mercaptopyrimidine in mixed solvent(c. HCI : ethanol : H20 = 1:1:8 (v/v)). then, 2-mercaptopyrimidine is detected on Gas Chromatography/Flame Ionization Detector but thiourea is not. 2-mercaptopyrimidine's Low Detection Limit is about 100ppm(mg/l).