원문정보
초록
영어
Hepatitis B virus is the leading source of liver disorders and is a global health problem and needs advancements in its treatment against increasing problems. Recently five vanitaracin derivatives were isolated from the fungus Talaromyces species which have anti-Hepatitis B virus activity. Hence, in the present study, molecular docking was carried out with five vanitaracin derivatives isolated from Talaromyces species and three known inhibitors.The objective of this work is to study the interaction of newly isolated compounds and compare its interaction with known inhibitors. The docking results revealed that vanitaracin derivatives have good interactions and has better docking score with the Hepatitis B virus and suggest SER2, SER4 and ASP30 are important residues involved in interaction with the inhibitors. These result authenticates vanitaracin derivatives contributes to inhibitory activity of Hepatitis B virus to treat liver disorders.
목차
1. Introduction
2. Materials and Methods
2.1. Protein Preparation
2.2. Ligand Preparation
2.3. Molecular Docking
3. Results and Discussion
3.1. Molecular Docking
4. Conclusion
References
키워드
- Hepatitis B Virus
- Talaromyces Species
- Molecular Docking.