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Purpose: The aims of this study are compare with microstructure and mechanical properties of Co-Cr-Mo alloys fabricated by powder metallurgy(P/M) process and casting process respectively. Method: Microstructure and micro-hardness were tested by SEM and Vickers Hardness Tester. The sintered specimen was produced by furnace-coolling after sintering, however the casting specimen were produced thru air-cooling and water-cooling after the casting. For observation of phase transformation during sintering, DSC analyzing was carried out. Results: Mean pore size of sintered Co-Cr-Mo alloy was 4.32㎛ and that of casting alloy was 1.63㎛. Hardness of sintered alloy was lower than water-quenched casting alloy. Conclusion: Proper sintering temperature of Co-Cr-Mo alloy was above 1,200℃ and pore size of casting specimen were finer than sintered specimen, but hardness were similar.