earticle

영어

Because of global climate change, mosquitos which are vectors for the dengue virus (DENV) are increasing in population and the incidence of dengue fever and dengue hemorrhagic fever is increasing every year in countries not only in the subtropics but also in other regions worldwide. There are 4 subtypes of DENV, each differing in infectivity and virulence. This study compared and analyzed genetic variation in the genomic sequences of DENV subtypes 1 and 2. The results showed that while non-synonymous codon variation was high in DENV-1, synonymous codon variation was also high in DENV-2. Additionally, there were differences in the genetic variation in each subtype according to the year or region, and incidence levels increased during periods when sequence variation was high. The results of this study can be used to compare the subtype-specific genetic variation characteristics of DENV to predict the incidence rates and sequence variations of DENV according to the region or year.