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Objectives: This study was to analyze the characteristics of published intervention studies and to evaluate the effectiveness of non-pharmacological interventions on alcoholics. Methods: To search for the intervention studies, web databases including RISS, KISS, NDSL, NANET, KMbase and KoreaMed were used. The main search strategy combined terms indicating non-pharmacological intervention and study design. Methodological quality was assessed using Cochrane’s Risk of Bias. Data were analyzed by the RevMan 5.3 program of Cochrane library. Results: A total of 3132 studies were retrieved. From these studies, 40 studies met the inclusion criteria with a total of 1036 participants. Two authors independently extracted data from the selected studies and assessed the methodological quality. Forty studies utilized various non-pharmacological interventions: eleven studies on music therapy (27.5%), six studies on cognitive behavior therapy (15%) and meditation (15%), four studies on art therapy (10%) and group therapy (10%), two studies on motivational interviewing (5%) and seven studies used other therapies. Non-pharmacological intervention was conducted for a mean of 6.5 weeks, 10.1 sessions and an average of 70.8 minutes per session. In the forty studies, non-pharmacological interventions had a significant effect on self-esteem (d= –0.76, p<.001, I2=33%), anxiety (d== –0.76, p<.001, I2=0%), positive emotion (d== –0.85, p<.001, I2=25%) and negative emotion (d== –0.68, p<.001, I2=0%). For heterogeneous effect sizes, subgroup analysis was done, and non-pharmacological interventions had a significant effect on interpersonal relationship (d== –0.98, p<.001, I2=0%). Conclusion: This study suggests that non-pharmacological interventions can assist alcoholics in strengthening self-esteem, positive emotion, and relationship and reducing anxiety and negative emotion on alcoholics. Further well-designed non-pharmacological intervention studies will lead to better understanding of the effect of treatments on alcoholics.