Original Article

국내 노인 파킨슨병 환자에서의 잠재적으로 부적절한 약물사용 현황에 대한 연구


Assessment of Potentially Inappropriate Medication Use in Korean Elderly Patients with Parkinson’s Disease

서미경, 배민경, 이인향, 전성실, 윤정현

피인용수 : 0(자료제공 : 네이버학술정보)



Objectives: The present study assessed the prevalence of the potentially inappropriate medication (PIM) use in Korean elderly patients with Parkinson’s disease. In addition, this study examined risk factors that affect PIM use. Method: A retrospective, observational study was conducted using Korean National Health Insurance claims database of 2009. PIM use in Parkinson’s disease patients aged 65 years or older was examined based on 2012 Beers Criteria. Multivariable logistic regression was conducted to identify risk factors for PIM use. Results: Among 5,277 elderly patients with Parkinson’s disease, 88.9% of patients used PIM(s) at least once. The average number of PIM items used per patient was 4.2. PIM use ratio, the proportion of total amount of PIMs to all medications per patient, was 12.6%. Frequently used PIM therapeutic classes were benzodiazepines (32.7%), firstgeneration antihistamines (19.2%), and prokinetics (17.5%). Individual PIMs most commonly used included chlorpheniramine (11.4%), levosulpiride (10.9%), diazepam (9.0%), and alprazolam (7.6%). Women (odds ratio [OR] 1.14, 95% confidence interval [CI] 1.11-1.16), medical aid (OR 1.18, 95% CI 1.15-1.21), and long-term facilities (OR 2.43, 95% CI 2.22- 2.65) were shown to be risk factors associated with PIM use. Of particular, wide variation in PIM use was associated with the types of healthcare facility. Conclusion: The PIM prevalence was very high in elderly Parkinson’s disease patients. Nationally effective and systematic efforts to identify and prevent PIM use should be made to ensure patient safety and to improve quality of care in the elderly.


 연구 방법
  연구 대상약물
  변수의 정의
 연구 결과
  연구대상의 특징
  Beers Criteria에 의한 PIM 사용현황 분석


  • 서미경 Mi-Kyung Seo. 부산대학교 약학대학
  • 배민경 Min Kyung Bae. 부산대학교 약학대학
  • 이인향 Iyn-Hyang Lee. 영남대학교 약학대학
  • 전성실 Seongsill Jeon. 왈레스 기념 침례병원 약제부
  • 윤정현 Jeong-Hyun Yoon. 부산대학교 약학대학


자료제공 : 네이버학술정보

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